Chemical Identification

Sequence and Structural Features

• Backbone derived from a modified GIP peptide scaffold
• Non-coded residues at positions 2 (Aib), 13 (α-methyl-L-leucine), and 20 (Aib)
• Aib substitution at position 2 confers resistance to DPP-4 cleavage
• C20 fatty diacid moiety conjugated via AEEA-γGlu linker at Lys17 for albumin binding and extended half-life
• C-terminal amidation

Receptor Binding Profile (in vitro)

Source: Coskun et al., Cell Metabolism, 2022.

Storage and Handling

• Lyophilized form: store at -20°C, protected from light and moisture, sealed under inert atmosphere where possible
• Shelf life (lyophilized, -20°C): up to 24 months
• Reconstituted solution: store at 2–8°C; aliquot to minimize freeze-thaw cycles
• Recommended reconstitution solvent: bacteriostatic water or sterile water for laboratory use
• Avoid repeated freeze-thaw; peptide integrity may degrade with multiple cycles

Research Context

Retatrutide is classified as an investigational compound and has been described in peer-reviewed literature as a tool for studying multi-receptor GPCR pharmacology, incretin signaling, and triple-agonist peptide engineering.

Selected published references:

• Coskun T, et al. Cell Metabolism 34(9):1234–1247 (2022)
• Rosenstock J, et al. The Lancet 402(10401):529–544 (2023)
• Jastreboff AM, et al. New England Journal of Medicine 389:514–526 (2023)
• Sanyal AJ, et al. Nature Medicine 30(7):2037–2048 (2024)

These citations are provided for scientific reference only and do not constitute any claim regarding the suitability of this compound for any use outside of controlled laboratory research.

Documentation

A batch-specific Certificate of Analysis documenting identity, purity, and composition is available for download on this product page. Third-party analytical verification is performed on every batch prior to release.

Research Use Statement

This product is sold exclusively for in vitro laboratory research purposes. It is not a drug, food, cosmetic, or dietary supplement. It is not intended for human or veterinary use, consumption, application, or administration. It has not been approved by the U.S. Food and Drug Administration to diagnose, treat, cure, or prevent any disease or medical condition.

Buyer Acknowledgment

By purchasing this product, the buyer confirms that they are: (1) at least 21 years of age; (2) a qualified researcher, laboratory, or research organization; (3) purchasing this compound strictly for in vitro laboratory research conducted in accordance with all applicable federal, state, and local laws; and (4) assuming full responsibility for the handling, storage, and use of this compound in accordance with accepted laboratory practices.